ironjustice
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 Posted: Wed Mar 05, 2008 4:16 pm Post subject: Iron Targeting In Neurodegeneration |
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"Edaravone is safe and may delay the progression of functional motor
disturbances"
Investigation of the therapeutic effects of edaravone, a free radical
scavenger, on amyotrophic lateral sclerosis (Phase II study). [Journal
Article]
Amyotroph Lateral Scler 2006 Dec; 7(4):247-51.
Yoshino H, Kimura A
Amyotrophic lateral sclerosis (ALS) is a rare disease involving
selective and progressive degeneration and disappearance of motor
neurons.
Oxidative stress is believed to contribute to its pathogenesis.
We have investigated the efficacy and safety of edaravone, a free
radical scavenger previously approved for treatment of acute cerebral
infarction, in ALS patients.
Within an open trial design, 20 subjects with ALS received either 30
mg (5 subjects) or 60 mg (15 subjects) of edaravone via intravenous
drip once per day.
Two weeks of administration was followed by a two-week observation
period.
This four-week cycle was repeated six times.
The primary endpoint was the change in the revised ALS functional
rating scale (ALSFRS-R) score, while the secondary endpoint was 3-
nitrotyrosine (3NT) level in cerebrospinal fluid (CSF). Efficacy was
evaluated in the 60 mg group.
During the six-month treatment period, the decline in the ALSFRS-R
score (2.3+/-3.6 points) was significantly less than that in the six
months prior to edaravone administration (4.7+/-2.1 points); the
difference between the two was 2.4+/-3.5 points (Wilcoxon signed rank
test, p = 0.039).
In almost all patients, CSF 3NT, a marker for oxidative stress, was
markedly reduced to almost undetectable levels at the end of the six-
month treatment period.
Data from the present study suggest that edaravone is safe and may
delay the progression of functional motor disturbances by reducing
oxidative stress in ALS patients.
Amyotrophic lateral sclerosis : official publication of the World
Federation of Neurology Research Group on Motor Neuron Diseases
[Amyotroph Lateral Scler]
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http://tinyurl.com/ynpdhm
"Iron-chelating agents, N-acetyl-L-cysteine (NAC), apocynin,probucol,
and edaravone, are useful in preventing cardiovascular injury and
diseases."
Recent Patents on Anti-Infective Drug Discovery, 2006, 1,
17-31171574-891X/06 $100.00+.00(c) 2006 Bentham Science Publishers
Ltd.Recent Progress in Pharmacological Research of Antioxidants
inPathological Conditions: Cardiovascular Health
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