Targeting Iron In Diabetes

ironjustice · Guest

The radical scavenger edaravone counteracts diabetes in multiple low-
dose streptozotocin-treated mice. [JOURNAL ARTICLE]
Eur J Pharmacol 2008 Feb 5.
Fukudome D, Matsuda M, Kawasaki T, Ago Y, Matsuda T

Edaravone is a potent scavenger of hydroxyl radicals and attenuates
oxidative damage-related neurodegenerative diseases. Previous studies
suggest that oxidative stress plays a key role in the pathogenesis of
diabetes. The present study examined the effect of edaravone on
diabetes in multiple low-dose streptozotocin-treated mice. Mice
treated with low-doses of streptozotocin for five consecutive days
showed progressive hyperglycemia and an increased incidence of
diabetes. Daily treatment with edaravone during the streptozotocin
injections counteracted the multiple low-dose streptozotocin-induced
hyperglycemia in a dose-dependent manner. Edaravone protected against
the multiple low-dose streptozotocin-induced reduction in pancreatic
insulin. The suppressive effects of edaravone were also observed when
it was administered after the last injection of streptozotocin.
Histochemical examination showed that multiple low-dose streptozotocin
treatment caused mononuclear cell infiltration in pancreatic islets,
followed by hyperglycemia, and that edaravone significantly inhibited
the multiple low-dose streptozotocin-induced insulitis. Multiple low-
dose streptozotocin treatment also increased the lipid peroxidation
product thiobarbituric acid reactive substance in pancreatic tissues
of mice, and this effect was completely inhibited by edaravone. These
findings suggest that edaravone, even after streptozotocin treatment,
counteracts the development of multiple low-dose streptozotocin-
induced diabetes by scavenging free radicals, which are possible
mediators of the immune destruction of islet beta cells.

European journal of pharmacology [Eur J Pharmacol]
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http://tinyurl.com/ynpdhm

"Iron-chelating agents, N-acetyl-L-cysteine (NAC), apocynin,probucol,
and edaravone, are useful in preventing cardiovascular injury and
diseases."

Recent Patents on Anti-Infective Drug Discovery, 2006, 1,
17-31171574-891X/06 $100.00+.00(c) 2006 Bentham Science Publishers
Ltd.Recent Progress in Pharmacological Research of Antioxidants
inPathological Conditions: Cardiovascular Health

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