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 Posted: Tue Mar 04, 2008 5:01 pm Post subject: Rusting Away In Arthritisville |
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"Confirms the role of oxidative stress in rheumatoid arthritis"
Lipid, protein, DNA oxidation and antioxidant status in rheumatoid
arthritis. [JOURNAL ARTICLE]
Clin Biochem 2008 Feb 15.
Seven A, Güzel S, Aslan M, Hamuryudan V
OBJECTIVES: To investigate lipid, protein, DNA oxidation and
antioxidant status in blood and synovial fluid of rheumatoid arthritis
(RA) patients and to determine the importance of oxidative stress
parameters in reflecting disease activity.
DESIGN AND METHODS: 20 RA patients and 15 healthy controls were
included. Lipid peroxidation (thiobarbituric acid reactive substances
(TBARS), lipid hydroperoxide, and conjugated diene), protein oxidation
(carbonyl and thiol), DNA oxidation (8-OHdG) and antioxidant status
markers (glutathione (GSH), glutathione peroxidase (GSH Px),
superoxide dismutase (CuZn SOD), and catalase) were determined in
blood and synovial fluid.
RESULTS: TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated
diene (p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were
significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH
Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly lower
in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide
(p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG
(p<0.05) levels were significantly higher, catalase activity (p<0.001)
significantly lower in synovial fluid of RA patients.
CONCLUSIONS: Increased lipid, protein and DNA oxidation markers and
impaired antioxidant status confirm the role of oxidative stress in
the pathogenesis of RA. Lipid peroxidation markers can serve as
surrogate markers for disease activity.
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